BMS-863233

Catalog NO.:A903999
CAS NO.:1169558-38-6
MDL NO.:
EINECS NO.:
Synonyms: XL413;(S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one
Quality Control & MSDS
Product Details
CAS NO.:1169558-38-6
Appearance:
Molecular Formula:C14H12ClN3O2
Formula Weight:289.72
Melting Point:
Boiling Point:
Flash Point:
Density:
Storage Condition:Store in a tightly closed container, in a cool and dry place.
Description

BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.

1169562-71-3 (HCl)

1169558-38-6 (free base)

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