LT-673

Catalog NO.:A903997
CAS NO.:1207454-56-5
MDL NO.: MFCD20488024
EINECS NO.:
Synonyms: 5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
Quality Control & MSDS
Product Details
CAS NO.:1207454-56-5
Appearance:
Molecular Formula:C19H14F2N6O
Formula Weight:380.36
Melting Point:
Boiling Point:
Flash Point:
Density:
Storage Condition:Store in a tightly closed container, in a cool and dry place.
Description

Talazoparib, also known as BMN-673 and MDV-3800, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity (PARP1 IC50 = 0.57 nmol/L). Talazoparib acts as an inhibitor of poly ADP ribose polymerase(PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage. Talazoparib is theorized to have a higher potency than olaparib due to the additional mechanism of action called PARP trapping. PARP trapping is the mechanism of action where the PARP molecule is trapped on the DNA, which interferes with the cells ability to replicate. Talazoparib is found to be ~100 fold more efficient in PARP trapping than olaparib.

1373431-65-2 (tosylate)

1207456-01-6 (free base)

1207454-56-5 (racemic)

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