G007LK

Catalog NO.:A900891
CAS NO.:1380672-07-0
MDL NO.:
EINECS NO.:
Synonyms: (E)-4-(5-(2-(4-(2-chlorophenyl)-5-(5-(methylsulfonyl)pyridin-2-yl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)benzonitrile
Quality Control & MSDS
Product Details
CAS NO.:1380672-07-0
Appearance:
Molecular Formula:C25H16ClN7O3S
Formula Weight:529.07
Melting Point:
Boiling Point:
Flash Point:
Density:
Storage Condition:Store in a tightly closed container, in a cool and dry place.
Description

G007-LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1/2 inhibitor. G007-LK displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice. G007-LK was first discovered by Dr. Stefan Krauss's team.

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