IC 261

Catalog NO.:A900887
CAS NO.:186611-52-9
MDL NO.:
EINECS NO.:
Synonyms: SU 5607;1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one
Quality Control & MSDS
Product Details
CAS NO.:186611-52-9
Appearance:
Molecular Formula:C18H17NO4
Formula Weight:311.33
Melting Point:
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Flash Point:
Density:
Storage Condition:Store in a tightly closed container, in a cool and dry place.
Description

IC261, also known as SU5607, is a potent and selective CK1 inhibitor. IC261 triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. At low micromolar concentrations IC261 inhibits cytokinesis causing a transient mitotic arrest. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. IC261 binds to tubulin with an affinity similar to colchicine and is a potent inhibitor of microtubule polymerization. This activity accounts for many of the diverse biological effects of IC261 and, most importantly, for its selective cancer cell killing.

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