SB 366791

Catalog NO.:A900888
CAS NO.:472981-92-3
MDL NO.:
EINECS NO.:
Synonyms: 3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
Quality Control & MSDS
Product Details
CAS NO.:472981-92-3
Appearance:
Molecular Formula:C16H14NO2Cl
Formula Weight:287.74
Melting Point:
Boiling Point:
Flash Point:
Density:
Storage Condition:Store in a tightly closed container, in a cool and dry place.
Description

SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nM
target: VR1/TRPV1
IC 50: 5.7±1.2 nM [1]
SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08. Schild analysis indicated a competitive mechanism of action with a pA2 of 7.71.[1] SB-366791 showed a concentration-dependent potentiation of pH 5-induced 45Ca2+uptake in CHO cells expressing rat TRPV1 but not in untransfected cells[2]

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