Cipargamin, also known as NITD609, GNF-609 and KAE609, is a potent Spiroindolone inhibitor of Plasmodium falciparum growth with potent, dose-dependent antimalarial activity against asexual and sexual stages of Plasmodium. NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector.