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[CAS No.1145869-35-7] A900707 4'-C-Azido-2'-deoxy-2'-fluorocytidine 97%

Purity	Size	Price	Consult
97%	50mg	$1450.00
97%	100mg	$2500.00

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Product Details [1145869-35-7]

CAS Number: 1145869-35-7

MDL No.:

Catalog Number: A900707

EINECS:

Molecular Formula: C₉H₁₁FN₆O₄

Molecular Weight: 286.22

Boiling point:

Melting point:

Flash point:

Density:

Appearance: White powder

Storage: Store in 2-8°C for long term (months)

Chiral Purity:

Optical Rotation:

Refractivity:

Pubchem ID: 42638010

Synonyms: 4-amino-1-((2R,3R,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

Smiles: C1(=O)N([C@H]2[C@H](F)[C@H](O)[C@@](N=[N+]=[N-])(CO)O2)C=CC(N)=N1

InchiKey: KTOLOIKYVCHRJW-JVZYCSMKSA-N

Inchi: InChI=1S/C9H11FN6O4/c10-5-6(18)9(3-17,14-15-12)20-7(5)16-2-1-4(11)13-8(16)19/h1-2,5-7,17-18H,3H2,(H2,11,13,19)/t5-,6+,7-,9-/m1/s1

Safety [1145869-35-7]

GHS Pictogram:

Signal Word: Warning

Class:

Precautionary Statements: P261;P305+P351+P338

UN No.:

Hazard Statements: H302;H315;H319;H335

Packing Group:

Literatures [1145869-35-7]

Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases

Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases

Michael O Clarke 1, Richard Mackman 2, Daniel Byun 1, Hon Hui 1, Ona Barauskas 1, Gabriel Birkus 1, Byoung-Kwon Chun 1, Edward Doerffler 1, Joy Feng 1, Kapil Karki 1, Gary Lee 1, Michel Perron 1, Dustin Siegel 1, Swami Swaminathan 1, William Lee 1

Affiliations Expand

PMID: 25978965
DOI: 10.1016/j.bmcl.2015.04.073

Abstract

Novel 4'-substituted β-d-2'-deoxy-2'-α-fluoro (2'd2'F) nucleoside inhibitors of respiratory syncytial virus (RSV) are reported. The introduction of 4'-substitution onto 2'd2'F nucleoside analogs resulted in compounds demonstrating potent cell based RSV inhibition, improved inhibition of the RSV polymerase by the nucleoside triphosphate metabolites, and enhanced selectivity over incorporation by mitochondrial RNA and DNA polymerases. Selectivity over the mitochondrial polymerases was found to be extremely sensitive to the specific 4'-substitution and not readily predictable. Combining the most potent and selective 4'-groups from N-nucleoside analogs onto a 2'd2'F C-nucleoside analog resulted in the identification of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a promising nucleoside lead for RSV.

Keywords: DNA polymerase γ; Mitochondria; Mitochondrial RNA polymerase; Nucleoside; Respiratory syncytial virus.

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