Iptacopan hydrochloride,1646321-63-2-Amadis Chemical

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[CAS No.1646321-63-2] A937938 Iptacopan hydrochloride 98%

Purity	Size	Price
98%	25mg	$219.00
98%	50mg	$371.00
98%	100mg	$630.00
98%	250mg	$1196.00

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Quality Control of [1646321-63-2]

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Product Details [1646321-63-2]

CAS Number: 1646321-63-2

MDL No.: MFCD32701924

Catalog Number: A937938

EINECS:

Molecular Formula: C₂₅H₃₁ClN₂O₄

Molecular Weight: 458.98

Boiling point:

Melting point:

Flash point:

Density:

Appearance:

Storage: Store in -20°C for long term (months)

Chiral Purity:

Optical Rotation:

Refractivity:

Pubchem ID: 117823351

Synonyms: 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid hydrochloride

Smiles: O=C(O)C1=CC=C([C@H]2N(CC3=C(OC)C=C(C)C4=C3C=CN4)CC[C@H](OCC)C2)C=C1.[H]Cl

InchiKey: SEZXOFFLNHXEJE-CQERKEQDSA-N

Inchi: InChI=1S/C25H30N2O4.ClH/c1-4-31-19-10-12-27(22(14-19)17-5-7-18(8-6-17)25(28)29)15-21-20-9-11-26-24(20)16(2)13-23(21)30-3;/h5-9,11,13,19,22,26H,4,10,12,14-15H2,1-3H3,(H,28,29);1H/t19-,22-;/m0./s1

Safety [1646321-63-2]

GHS Pictogram:

Signal Word: Warning

Class:

Precautionary Statements: P261;P305+P351+P338

UN No.:

Hazard Statements: H302;H315;H319;H335

Packing Group:

Literatures [1646321-63-2]

Sorry, the literature is not available.

Similar of [1646321-63-2]

A935227 1644670-37-0

Iptacopan

Reason:Inhibitors/Agonists

Description [1646321-63-2]

Iptacopan, also known as LNP023, is a complement Factor B Inhibitor (IC50=10 nM). LNP023 improves LN in MRL/lpr mice. The mechanism is as follows: LNP023 binds to CFB to inhibit the activation of the alternative complement pathway. LNP023 treatment for LN may also play a role in regulating the protein expression of AKT, TNF-α, and STST3. LNP023 showed low clearance and high bioavailability (62.2%). Furthermore, four minor metabolites from rat plasma were detected and identified by LC combined with high-resolution mass spectrometry. The metabolic pathways were O-deethylation (M1), hydroxylation (M4), oxidation (M3), and acyl-glucuronidation (M2).

1646321-63-2 (HCl) 1644670-37-0 (free base)