(+)-PD 128907 hydrochloride

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For R&D use only.

Catalog NO.：A820165
CAS No. : 300576-59-4
Molecular Formula：C₁₄H₂₀ClNO₃
Molecular Weight： 285.77

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COA NMR

Product Details

CAS Number	300576-59-4	Appearance	Off-white powder
Catalog Number	A820165	MDL Number	MFCD00210210
Molecular Formula	C₁₄H₂₀ClNO₃	Molecular Weight	285.77
Boiling Point	389°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	(4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

937263-43-9 (Arry-380)

937265-83-3 (ARRY-380 analog)

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H200	Explosives (Unstable Explosive)
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