For R&D use only.

(+)-PD 128907 hydrochloride

  • Catalog NO.:A820165
  • CAS No. : 300576-59-4
  • Molecular Formula:C14H20ClNO3
  • Molecular Weight: 285.77
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Product Details

CAS Number 300576-59-4 Appearance Off-white powder
Catalog Number A820165 MDL Number MFCD00210210
Molecular Formula C14H20ClNO3 Molecular Weight 285.77
Boiling Point 389°C at 760 mmHg Melting Point
Flash Point Density
Synonyms (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H315-H319-H335 Class
Precautionary Statements P261-P305+P351+P338 Packing Group

Description

Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

937263-43-9 (Arry-380)

937265-83-3 (ARRY-380 analog)

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(+)-PD 128907 hydrochloride
(4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride