(+)-PD 128907 hydrochloride
- Catalog NO.：A820165
- CAS No. : 300576-59-4
- Molecular Formula：C14H20ClNO3
- Molecular Weight： 285.77
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|CAS Number||300576-59-4||Appearance||Off-white powder|
|Catalog Number||A820165||MDL Number||MFCD00210210|
|Molecular Formula||C14H20ClNO3||Molecular Weight||285.77|
|Boiling Point||389°C at 760 mmHg||Melting Point|
|Storage Condition||Store in a tightly closed container,in a cool and dry place|
|Signal Word||Warning||UN Number|
|Precautionary Statements||P261-P305+P351+P338||Packing Group|
Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.