For R&D use only.


  • Catalog NO.:A854208
  • CAS No. : 1268524-70-4
  • Molecular Formula:C23H25ClN4O2S
  • Molecular Weight: 456.99
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Product Details

CAS Number 1268524-70-4 Appearance White powder
Catalog Number A854208 MDL Number MFCD22683748
Molecular Formula C23H25ClN4O2S Molecular Weight 456.99
Boiling Point Melting Point
Flash Point Density
Synonyms tert-butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Storage Condition Store in a tightly closed container,in a cool and dry place


GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H302-H315-H319-H332-H335 Class
Precautionary Statements P261-P280-P305+P351+P338 Packing Group


(+)-JQ1 is a BET potent BET bromodomain Inhibitor. Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1 has antiproliferative activity against many cancers, mainly through inhibition of c-MYC and upregulation of p21. JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer. JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. JQ1 disrupts human dendritic cell maturation by inhibiting STAT5.

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tert-butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate