3-Bromo-1-methyl-1H-1,2,4-triazole

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For R&D use only.

Catalog NO.：A831116
CAS No. : 56616-91-2
Molecular Formula：C₃H₄BrN₃
Molecular Weight： 161.99

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Quality Control&SDS

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Product Details

CAS Number	56616-91-2	Appearance	White solid
Catalog Number	A831116	MDL Number	MFCD11109755
Molecular Formula	C₃H₄BrN₃	Molecular Weight	161.99
Boiling Point		Melting Point
Flash Point		Density
Synonyms	3-Bromo-1-methyl-1H-1,2,4-triazole
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.

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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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