- Catalog NO.：A854415
- CAS No. : 202590-98-5
- Molecular Formula：C25H22ClN5O2S
- Molecular Weight： 491.99
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|CAS Number||202590-98-5||Appearance||Off-white to light yellow powder|
|Catalog Number||A854415||MDL Number||MFCD26960949|
|Molecular Formula||C25H22ClN5O2S||Molecular Weight||491.99|
|Boiling Point||Melting Point|
|Synonyms||OTX 015; MK-8628;(S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide; OTX-015; OTX015; OTX 015; MK-8628; MK 8628; MK8628|
|Storage Condition||Store in a tightly closed container,in a cool and dry place|
|Signal Word||Warning||UN Number|
|Precautionary Statements||P261-P305+P351+P338||Packing Group|
Birabresib, also known as OTX015 and MK-8628, a potent BET bromodomian inhibitor, which targets the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4). BRDs 2, 3, and 4 are considered potential cancer targets because of their pivotal role in regulating the transcription of growth-promoting genes and cell cycle regulators. OTX015 is the first BRD2/3/4 inhibitor to enter clinical trials. OTX015 showed antiproliferative activity in a large panel of cell lines derived from mature B-cell lymphoid tumors with median IC50 of 240 nmol/L, without significant differences among the different histotypes.