4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Home > Products>4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

For R&D use only.

Catalog NO.：A946975
CAS No. : 1440520-87-5
Molecular Formula：C₁₀H₁₇BN₂O₂
Molecular Weight： 208.07

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	1440520-87-5	Appearance	White powder
Catalog Number	A946975	MDL Number	MFCD27977041
Molecular Formula	C₁₀H₁₇BN₂O₂	Molecular Weight	208.07
Boiling Point		Melting Point
Flash Point		Density
Synonyms	Methyl-1H-pyrazole-3-boronic acid pinacol ester 英文名称：4-Methyl-1H-pyrazole-3-boronic acid pinacol ester
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302;H315;H319;H335	Class
Precautionary Statements	P261;P305+P351+P338	Packing Group

Description

BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor. BMS-582949 is currently under Phase II clinical trials for the treatment of inflammatory diseases. One clinical study showed that, in stable atherosclerosis, 12 weeks of treatment with BMS-582949 did not reduce arterial inflammation or hs-CRP compared to placebo, whereas intensification of statin therapy significantly decreased arterial inflammation. p38α MAP kinase plays a crucial role in regulating the biosynthesis of many inflammatory cytokines including TNFα and IL-1β.

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