(R)-N,N-Dimethylpiperidin-3-amine dihydrochloride
- Catalog NO.：A944087
- CAS No. : 1152110-75-2
- Molecular Formula：C7H18Cl2N2
- Molecular Weight： 201.14
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Product Details
| CAS Number | 1152110-75-2 | Appearance | |
| Catalog Number | A944087 | MDL Number | |
| Molecular Formula | C7H18Cl2N2 | Molecular Weight | 201.14 |
| Boiling Point | Melting Point | ||
| Flash Point | Density | ||
| Synonyms | (R)-N,N-Dimethylpiperidin-3-amine dihydrochloride | ||
| Storage Condition | Store in a tightly closed container,in a cool and dry place | ||
Safety
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| Signal Word | Warning | UN Number | |
| Hazard Statements | Class | ||
| Precautionary Statements | Packing Group | ||
Description
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Nintedanib, also known as BIBF1120, is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs). Nintedanib inhibits the following RTKs: platelet-derived growth factor receptor (PDGFR) α and β, fibroblast growth factor receptor (FGFR) 1-3, vascular endothelial growth factor receptor (VEGFR) 1-3, and Fms-like tyrosine kinase-3 (FLT3). Nintedanib binds competitively to the adenosine triphosphate (ATP) binding pocket of these receptors and blocks the intracellular signaling which is crucial for the proliferation, migration, and transformation of fibroblasts representing essential mechanisms of the IPF pathology. Nintedanib esylate was approved in 2014 for the treatment of idiopathic pulmonary fibrosis (IPF). |
