DAMGO (trifluoroacetate salt)

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Catalogo NO.：A950589
Numero CAS : 78123-71-4
Formula molecolare：C₂₈H₃₆F₃N₅O₈
Peso molecolare： 627.62

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Dettagli del prodotto

Numero CAS	78123-71-4	Aspetto
Numero di catalogo	A950589	Numero MDL	MFCD00076432
Formula molecolare	C₂₈H₃₆F₃N₅O₈	Peso molecolare	627.62
Punto di ebollizione		Punto di fusione
Punto d'infiammabilità		Densità
Sinonimi	(S)-2-Amino-N-((R)-1-((2-(((S)-1-((2-hydroxyethyl)amino)-1-oxo-3-phenylpropan-2-yl)(methyl)amino)-2-oxoethyl)amino)-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)propanamide trifluoroacetate salt
Condizioni di conservazione	Store in a tightly closed container,in a cool and dry place

Sicurezza

Pittogramma GHS
AVVERTENZA	Warning	Numero ONU
Dichiarazioni di pericolo	H302;H315;H319;H335	Classe
Consigli di prudenza	P261;P305+P351+P338	Gruppo di imballaggio

Descrizione

Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. DM1 can also be linked to an antibody using the SMCC (4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid) linker, in which case the International Nonproprietary Name of the conjugate formed contains the word emtansine. DM1 and its attachment via these linkers result from ImmunoGen Inc research. Trastuzumab emtansine (T-DM1) is an anti-HER2/neu antibody-drug conjugate.

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H200	Explosives (Unstable Explosive)
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H318	Serious eye damage/eye irritation (Category 1)
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H330	Acute toxicity,inhalation (Category 1, 2)
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H334	Sensitisation, respiratory (Category 1)
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