Iptacopan,1644670-37-0-Amadis Chemical

Home > Product Catalog > Life science > Inhibitors/Agonists > Iptacopan

[CAS No.1644670-37-0] A935227 Iptacopan 98%

Purity	Size	Price
98%	5mg	$270.00
98%	10mg	$459.00
98%	25mg	$558.00
98%	50mg	$675.00
98%	100mg	$814.00
98%	250mg	$1535.00

Note*

1.Please click to confirm the discount and stock quantity.

2.Click”Bulk Inquiry”to ask for quotations of other quantity.

3.The price does not include shipping and bank charges.

Bulk Inqulry

Quality Control of [1644670-37-0]

NMR

CNMR

HPLC

LC-MS

Related Doc. of[1644670-37-0]

SDS

Specification

MOL

SDF

Product Details [1644670-37-0]

CAS Number: 1644670-37-0

MDL No.: MFCD32174282

Catalog Number: A935227

EINECS:

Molecular Formula: C₂₅H₃₀N₂O₄

Molecular Weight: 422.52

Boiling point: 599.1±50.0 °C

Melting point:

Flash point:

Density: 1.25±0.1 g/cm3

Appearance:

Storage: Store in -20°C for long term (months)

Chiral Purity:

Optical Rotation:

Refractivity:

Pubchem ID: 90467622

Synonyms: 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid

Smiles: O(CC)[C@H]1CCN(CC2=C(C=C(C)C3=C2C=CN3)OC)[C@H](C2C=CC(C(=O)O)=CC=2)C1

InchiKey: RENRQMCACQEWFC-UGKGYDQZSA-N

Inchi: InChI=1S/C25H30N2O4/c1-4-31-19-10-12-27(22(14-19)17-5-7-18(8-6-17)25(28)29)15-21-20-9-11-26-24(20)16(2)13-23(21)30-3/h5-9,11,13,19,22,26H,4,10,12,14-15H2,1-3H3,(H,28,29)/t19-,22-/m0/s1

Safety [1644670-37-0]

GHS Pictogram:

Signal Word: Warning

Class:

Precautionary Statements: P261;P305+P351+P338

UN No.:

Hazard Statements: H302;H315;H319;H335

Packing Group:

Literatures [1644670-37-0]

Sorry, the literature is not available.

Similar of [1644670-37-0]

A937938 1646321-63-2

Iptacopan hydrochloride

Reason:Inhibitors/Agonists

Description [1644670-37-0]

Iptacopan, also known as LNP023, is a complement Factor B Inhibitor (IC50=10 nM). LNP023 improves LN in MRL/lpr mice.

The mechanism is as follows: LNP023 binds to CFB to inhibit the activation of the alternative complement pathway.

LNP023 treatment for LN may also play a role in regulating the protein expression of AKT, TNF-α, and STST3.

LNP023 showed low clearance and high bioavailability (62.2%).

Furthermore, four minor metabolites from rat plasma were detected and identified by LC combined with high-resolution mass spectrometry.

The metabolic pathways were O-deethylation (M1), hydroxylation (M4), oxidation (M3), and acyl-glucuronidation (M2).

1646321-63-2 (HCl) 1644670-37-0 (free base)

Browsing history

A1148069 2254577-43-8

Inquiry

Detail

A899173 138330-18-4

Disodium Cycloheptylaminomethylene Diphosphonate

Inquiry

Detail

A1205539 5140-03-4 97%

1,4-Bis(2-hydroxyethyl)benzene

$357.00 5g

Detail

A821482 3287-99-8 97%

Benzylamine hydrochloride

$224.00 500g

Detail

A1139256 1975119-26-6

1H-Pyrazole, 1-(2-fluoro-4-nitrophenyl)-4-methyl-3-(trifluoromethyl)-

Inquiry

Detail

A1055304 852042-07-0 97%

4,8-Ditert-butyl-6-[(2S,4S)-4-(4,8-ditert-butyl-2,10-dimethoxybenzo[d][1,3,2]benzodioxaphosphepin-6-yl)oxypentan-2-yl]oxy-2,10-dimethoxybenzo[d][1,3,2]benzodioxaphosphepine

$464.00 1g

Detail

A1221042 246869-07-8 97%

2-cyclopropoxyacetic acid

$167.00 50mg

Detail

A1217709 151373-08-9 97%

$213.00 250mg

Detail

A1111801 1240569-81-6 97%

4-Bromo-2-{[(butan-2-yl)amino]methyl}phenol hydrochloride

$626.00 2g

Detail

A1150648 2254574-26-8

Inquiry

Detail

A802089 109806-71-5 97%

4-(p-Chloro-a-phenylbenzyl)-1-piperazineethanol

$534.00 5g

Detail