For R&D use only.

(R)-6-(Benzyloxy)-8-(2-chloro-1-hydroxyethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

  • Catalog NO.:A915785
  • CAS No. : 869478-11-5
  • Molecular Formula:C17H16ClNO4
  • Molecular Weight: 333.77
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Product Details

CAS Number 869478-11-5 Appearance
Catalog Number A915785 MDL Number MFCD29920844
Molecular Formula C17H16ClNO4 Molecular Weight 333.77
Boiling Point 564.0±50.0 °C Melting Point
Flash Point Density 1.351±0.06 g/cm3
Synonyms 6-benzyloxy-8-((R)-2-chloro-1-hydroxy-ethyl)-4H-benzo[1,4]-oxazin-3-one
Storage Condition Store in a tightly closed container,in a cool and dry place

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Description

Tavaborole, also known as AN-2690 (trade name Kerydin) is a topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed. Tavaborole began its Phase 3 trials in December 2010 and was approved in July 2014. Tavaborole inhibits an essential fungal enzyme, Leucyl-tRNA synthetase, or LeuRS, required for protein synthesis. The inhibition of protein synthesis leads to termination of cell growth and cell death, eliminating the fungal infection. No treatment-related systemic side effects were observed in any of its clinical trials.

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(R)-6-(Benzyloxy)-8-(2-chloro-1-hydroxyethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
6-benzyloxy-8-((R)-2-chloro-1-hydroxy-ethyl)-4H-benzo[1,4]-oxazin-3-one