2-Bromo-4,6-difluoropyridine

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For R&D use only.

Catalog NO.：A873062
CAS No. : 41404-63-1
Molecular Formula：C₅H₂NF₂Br
Molecular Weight： 193.98

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Product Details

CAS Number	41404-63-1	Appearance
Catalog Number	A873062	MDL Number	MFCD09029860
Molecular Formula	C₅H₂NF₂Br	Molecular Weight	193.98
Boiling Point		Melting Point
Flash Point		Density
Synonyms	2-Bromo-4,6-difluoropyridine
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	2810
Hazard Statements	H227-H301-H311-H315-H319-H332-H335	Class	6.1
Precautionary Statements	P210-P261-P280-P301+P310-P305+P351+P338P210-P261-P280-P301+P310-P305+P351+P338	Packing Group	Ⅲ

Description

LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
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