Grapiprant
- Catalog NO.:A900379
- CAS No. : 415903-37-6
- Molecular Formula:C26H29N5O3S
- Molecular Weight: 491.61
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Product Details
CAS Number | 415903-37-6 | Appearance | White powder |
Catalog Number | A900379 | MDL Number | MFCD16628076 |
Molecular Formula | C26H29N5O3S | Molecular Weight | 491.61 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-((4-(2-Ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethyl)carbamoyl)-4-methylbenzenesulfonamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H303-H320 | Class | |
Precautionary Statements | P305+P351+P338 | Packing Group |
Description
Grapiprant, also known as CJ-023,423, RQ-00000007 and AAT-007, is a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic properties. In vitro, CJ-023,423 inhibits [(3)H]PGE(2) binding to both human and rat EP(4) receptors with K(i) of 13 +/- 4 and 20 +/- 1 nM, respectively. CJ-023,423 is highly selective for the human EP(4) receptor over other human prostanoid receptor subtypes. It also inhibits PGE(2)-evoked elevation in intracellular cAMP at the human and rat EP(4) receptors with pA(2) of 8.3 +/- 0.03 and 8.2 +/- 0.2 nM, respectively. In vivo, oral administration of CJ-023,423 significantly reduces thermal hyperalgesia induced by intraplantar injection of PGE(2) (ED(50) = 12.8 mg/kg). |