Cycloastragenol

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Catalog NO.：A864051
CAS No. : 84605-18-5
Molecular Formula：C₃₀H₅₀O₅
Molecular Weight： 490.72

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Product Details

CAS Number	84605-18-5	Appearance
Catalog Number	A864051	MDL Number	MFCD11618124
Molecular Formula	C₃₀H₅₀O₅	Molecular Weight	490.72
Boiling Point	617.2°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	(3b,6a,16b,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol;Cyclogalagenin
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling.

1706522-79-3 (HCl)

1415562-82-1 (free base)

1415562-83-2 (citrate)

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H200	Explosives (Unstable Explosive)
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