LCZ 696

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For R&D use only.

Catalog NO.：A855305
CAS No. : 936623-90-4
Molecular Formula：C₉₆H₁₂₀N₁₂Na₆O₂₁
Molecular Weight： 1915.99

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Product Details

CAS Number	936623-90-4	Appearance
Catalog Number	A855305	MDL Number	Not available
Molecular Formula	C₉₆H₁₂₀N₁₂Na₆O₂₁	Molecular Weight	1915.99
Boiling Point		Melting Point
Flash Point		Density
Synonyms	3-(1-Biphenyl-4-ylMethyl-3-ethoxycarbonyl-1-butylcarbaMoyl)propionate-3'-Methyl-2'-(pentanoyl(2'-(tetrazol-5-ylate)biphenyl-4'-ylMethyl)aMino)butyrate
Storage Condition	Store in a tightly closed container,in a cool and dry place

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Description

LCZ696 is a potent ARNi inhibitor and an investigational drug to treat heart failure. Chemically, LCZ696 is a mixture of valsartan and sacubitril in a 1:1 molar ratio. As of 2014 it is being developed by Novartis. LCZ696 is co-crystallized valsartan and sacubitril, in a one-to-one molar ratio. According to Sci-Finder database, LCZ696 has a formula as (valsartan)(sacubitril)(3Sodium)(5/2 hydrate), or (2 valsartan)(2 sacubitril) (6 Sodium)(5 hydrate), which has results C96H120N12Na6O21. Molecular Weight: 1915.99 . However, according to wikipedia, One LCZ696 complex consists of 6 valsartan anions, 6 sacubitril anions, 18 sodium cations, and 15 molecules of water, resulting in the molecular formula C288H330N36Na18O48·15H2O and a molecular mass of 5748.03 g/mol. The substance is a white powder consisting of thin hexagonal plates. It is stable in solid form as well as in aqueous (watery) solution with a pH of 5 to 7, and has a melting point of about 138 °C (280 °F).

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