(S)-3-Bromo-2-hydroxy-2-methylpropanoic acid

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For R&D use only.

Catalog NO.：A801387
CAS No. : 106089-20-7
Molecular Formula：C₄H₇BrO₃
Molecular Weight： 183.00

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Product Details

CAS Number	106089-20-7	Appearance
Catalog Number	A801387	MDL Number	MFCD09750950
Molecular Formula	C₄H₇BrO₃	Molecular Weight	183.00
Boiling Point	294.474°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	(S)-3-Bromo-2-hydroxy-2-methylpropanoic acid
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	3261
Hazard Statements	H314	Class	8
Precautionary Statements	P280-P305+P351+P338-P310	Packing Group	Ⅱ

Description

Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

937263-43-9 (Arry-380)

937265-83-3 (ARRY-380 analog)

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P370 + P378	In case of fire: Use … for extinction.
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P501	Dispose of contents/container to..…
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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
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H300	Acute toxicity,oral (Category 1, 2)
H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
H303	Acute toxicity,oral (Category 5)
H304	Aspiration hazard (Category 1)
H305	Aspiration hazard (Category 2)
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H311	Acute toxicity,dermal (Category 3)
H312	Acute toxicity,dermal (Category 4)
H313	Acute toxicity,dermal (Category 5)
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H317	Sensitisation, Skin (Category 1)
H318	Serious eye damage/eye irritation (Category 1)
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H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
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H341	Germ cell mutagenicity (Category 2)
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H361	Reproductive toxicity (Category 2)
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H371	Specific target organ toxicity, single exposure (Category 2)
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H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
H402	Hazardous to the aquatic environment, acute hazard (Category 3)
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