4,5-Dichloro-2-octylisothiazol-3(2H)-one
- Catalog NO.:A834730
- CAS No. : 64359-81-5
- Molecular Formula:C11H17Cl2NOs
- Molecular Weight: 282.23
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Product Details
CAS Number | 64359-81-5 | Appearance | |
Catalog Number | A834730 | MDL Number | MFCD04034673 |
Molecular Formula | C11H17Cl2NOs | Molecular Weight | 282.23 |
Boiling Point | 322.6°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 4,5-Dichloro-2-octylisothiazol-3(2H)-one | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H332-H335 | Class | |
Precautionary Statements | P261-P280-P305+P351+P338 | Packing Group |
Description
Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect. |