4-Vinylbenzocyclobutene

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For R&D use only.

Catalog NO.：A846069
CAS No. : 99717-87-0
Molecular Formula：C₁₀H₁₀
Molecular Weight： 130.19

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SDS COA HPLC/GC NMR

Product Details

CAS Number	99717-87-0	Appearance	Colourless liquid
Catalog Number	A846069	MDL Number	MFCD09834065
Molecular Formula	C₁₀H₁₀	Molecular Weight	130.19
Boiling Point	225.302°C at 760 mmHg	Melting Point
Flash Point	76℃	Density
Synonyms	4-vinyl-1,2-dihydrocyclobutabenzene;3-Vinylbicyclo[4.2.0]octa-1,3,5-triene
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H227-H302-H412	Class
Precautionary Statements	P210-P270-P273	Packing Group

Description

Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. DM1 can also be linked to an antibody using the SMCC (4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid) linker, in which case the International Nonproprietary Name of the conjugate formed contains the word emtansine. DM1 and its attachment via these linkers result from ImmunoGen Inc research. Trastuzumab emtansine (T-DM1) is an anti-HER2/neu antibody-drug conjugate.

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H200	Explosives (Unstable Explosive)
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