(S)-2-Amino-3-(4-bromo-1H-indol-3-yl)propanoic acid
- Catalog NO.:A870985
- CAS No. : 52448-16-5
- Molecular Formula:C11H11BrN2O2
- Molecular Weight: 283.13
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Product Details
CAS Number | 52448-16-5 | Appearance | |
Catalog Number | A870985 | MDL Number | MFCD10565749 |
Molecular Formula | C11H11BrN2O2 | Molecular Weight | 283.13 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (S)-2-Amino-3-(4-bromo-1H-indol-3-yl)propanoic acid | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
MMAE, also known as Monomethyl auristatin E, is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. MMAE is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. MMAE show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer. |