WDR5-0103

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For R&D use only.

Catalog NO.：A903601
CAS No. : 890190-22-4
Molecular Formula：C₂₁H₂₅N₃O₄
Molecular Weight： 383.44

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Product Details

CAS Number	890190-22-4	Appearance
Catalog Number	A903601	MDL Number	MFCD07086826
Molecular Formula	C₂₁H₂₅N₃O₄	Molecular Weight	383.44
Boiling Point		Melting Point
Flash Point		Density
Synonyms	methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	3077
Hazard Statements	H410	Class	9
Precautionary Statements	P273-P501	Packing Group	Ⅲ

Description

WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC50 = 39 µM). WD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription. WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis.

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H200	Explosives (Unstable Explosive)
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H318	Serious eye damage/eye irritation (Category 1)
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H330	Acute toxicity,inhalation (Category 1, 2)
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H333	Acute toxicity,inhalation (Category 5)
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