E2012

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For R&D use only.

Catalog NO.：A898090
CAS No. : 870843-42-8
Molecular Formula：C₂₅H₂₆FN₃O₂
Molecular Weight： 419.49

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Product Details

CAS Number	870843-42-8	Appearance
Catalog Number	A898090	MDL Number	MFCD11042274
Molecular Formula	C₂₅H₂₆FN₃O₂	Molecular Weight	419.49
Boiling Point	649.168°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	(S,E)-1-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one;E-2012
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H317-H319	Class
Precautionary Statements	P280-P305+P351+P338	Packing Group

Description

E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E2012 induces cataract in the rat by inhibiting DHCR24 at the final step of cholesterol synthesis with associated elevation in desmosterol within the lens, preceded by desmosterol changes that would serve as a predictive safety biomarker for lenticular opacity.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
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H300	Acute toxicity,oral (Category 1, 2)
H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
H303	Acute toxicity,oral (Category 5)
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H314	Skin corrosion/irritation (Category 1A, B, C)
H315	Skin corrosion/irritation (Category 2)
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H317	Sensitisation, Skin (Category 1)
H318	Serious eye damage/eye irritation (Category 1)
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H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
H336	Specific target organ toxicity,single exposure; Narcoticeffects (Category 3)
H340	Germ cell mutagenicity (Category 1A, 1B)
H341	Germ cell mutagenicity (Category 2)
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H351	Carcinogenicity (Category 2)
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H371	Specific target organ toxicity, single exposure (Category 2)
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H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
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H420	Hazardous to the ozone layer (Category 1)