3-Bromo-2-methoxyaniline

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For R&D use only.

Catalog NO.：A2400
CAS No. : 116557-46-1
Molecular Formula：C₇H₈BrNO
Molecular Weight： 202.05

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Quality Control&SDS

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Product Details

CAS Number	116557-46-1	Appearance	Light yellow to light brown liquid
Catalog Number	A2400	MDL Number	MFCD13186737
Molecular Formula	C₇H₈BrNO	Molecular Weight	202.05
Boiling Point	267.9°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	3-bromo-2-methoxybenzenamine;3-Bromo-2-methoxyaniline
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Sunitinib free base is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor. Sunitinib malate salt was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib inhibits cellular signaling by targeting multiple receptor tyrosine kinases (RTKs). The simultaneous inhibition of these targets therefore reduces tumor vascularization and triggers cancer cell apoptosis and thus results in tumor shrinkage. Sunitinib also inhibits CD117 (c-KIT), the receptor tyrosine kinase that (when improperly activated by mutation) drives the majority of gastrointestinal stromal cell tumors.

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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire: Use … for extinction.
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