4,6-Dibromodibenzo[b,d]furan

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For R&D use only.

Catalog NO.：A847739
CAS No. : 201138-91-2
Molecular Formula：C₁₂H₆Br₂O
Molecular Weight： 325.98

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	201138-91-2	Appearance
Catalog Number	A847739	MDL Number	MFCD00185686
Molecular Formula	C₁₂H₆Br₂O	Molecular Weight	325.98
Boiling Point		Melting Point
Flash Point		Density
Synonyms	4,6-Dibromodibenzo[b,d]furan
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H319-H413	Class
Precautionary Statements	P305+P351+P338	Packing Group

Description

Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.

1422144-42-0 (mesylate)

1254032-66-0 (free base)

1253952-02-1 (HCl)

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