For R&D use only.

(R)-(-)-3-quinuclidinol

  • Catalog NO.:A5118
  • CAS No. : 25333-42-0
  • Molecular Formula:C7H13NO
  • Molecular Weight: 127.18
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Product Details

CAS Number 25333-42-0 Appearance
Catalog Number A5118 MDL Number MFCD00211251
Molecular Formula C7H13NO Molecular Weight 127.18
Boiling Point 120 °C/27 MBAR Melting Point 217-224 °C
Flash Point Density 1.13g/cm3
Synonyms (3R)-1-azabicyclo[2.2.2]octan-3-ol
Storage Condition Store in a tightly closed container,in a cool and dry place

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Description

Birabresib, also known as OTX015 and MK-8628, a potent BET bromodomian inhibitor, which targets the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4). BRDs 2, 3, and 4 are considered potential cancer targets because of their pivotal role in regulating the transcription of growth-promoting genes and cell cycle regulators. OTX015 is the first BRD2/3/4 inhibitor to enter clinical trials. OTX015 showed antiproliferative activity in a large panel of cell lines derived from mature B-cell lymphoid tumors with median IC50 of 240 nmol/L, without significant differences among the different histotypes.

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(R)-(-)-3-quinuclidinol
(3R)-1-azabicyclo[2.2.2]octan-3-ol