For R&D use only.

tert-Butyl 4-hydroxybutanoate

  • Catalog NO.:A26857
  • CAS No. : 59854-12-5
  • Molecular Formula:C8H16O3
  • Molecular Weight: 160.21
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Quality Control&SDS
SDS COA NMR

Product Details

CAS Number 59854-12-5 Appearance Colorless liquid
Catalog Number A26857 MDL Number MFCD02684391
Molecular Formula C8H16O3 Molecular Weight 160.21
Boiling Point 228.9oC at 760 mmHg Melting Point 0.976 g/mL at 20oC
Flash Point >70℃(>158℉)(lit.) Density 0.976(lit.)
Synonyms 2-(2-hydroxyethyl)-3,3-dimethyl-butanoate;tert-Butyl 4-Hydroxybutanoate
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H227;H302;H320 Class
Precautionary Statements P305+P351+P338 Packing Group

Description

Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. DM1 can also be linked to an antibody using the SMCC (4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid) linker, in which case the International Nonproprietary Name of the conjugate formed contains the word emtansine. DM1 and its attachment via these linkers result from ImmunoGen Inc research. Trastuzumab emtansine (T-DM1) is an anti-HER2/neu antibody-drug conjugate. 

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tert-Butyl 4-hydroxybutanoate
2-(2-hydroxyethyl)-3,3-dimethyl-butanoate;tert-Butyl 4-Hydroxybutanoate