(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetic acid

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For R&D use only.

Catalog NO.：A865751
CAS No. : 75028-24-9
Molecular Formula：C₆H₈N₄O₃S
Molecular Weight： 216.22

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Product Details

CAS Number	75028-24-9	Appearance
Catalog Number	A865751	MDL Number	MFCD14583152
Molecular Formula	C₆H₈N₄O₃S	Molecular Weight	216.22
Boiling Point	430.5±28.0 °C	Melting Point	190-193°C (dec.)
Flash Point		Density	1.71
Synonyms	(Z)-1,2,3-trimethoxy-5-(4-methoxystyryl)benzene;
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H332-H335	Class
Precautionary Statements	P261-P280-P305+P351+P338	Packing Group

Description

Entinostat, also known as MS-275 or SNDX-275, is a potent HDAC inhibitor with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis.

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My Tracks: (Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetic acid

All chemicals are for R&D use only. Controlled products will be followed China law and buyer's country regulation.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
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H300	Acute toxicity,oral (Category 1, 2)
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H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
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