2,2'-(2,5-Dihydroxy-1,4-phenylene)diacetic acid

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For R&D use only.

Catalog NO.：A830392
CAS No. : 5488-16-4
Molecular Formula：C₁₀H₁₀O₆
Molecular Weight： 226.18

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	5488-16-4	Appearance	White powder
Catalog Number	A830392	MDL Number	MFCD00004325
Molecular Formula	C₁₀H₁₀O₆	Molecular Weight	226.18
Boiling Point	574.5°C at 760 mmHg	Melting Point	281-283°C (dec.)(lit.)
Flash Point	315.3°C	Density	1.602g/cm3
Synonyms	1,4-Benzenediacetic acid, 2,5-dihydroxy-; 2-[4-(carboxymethyl)-2,5-dihydroxyphenyl]acetic acid;
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. DM1 can also be linked to an antibody using the SMCC (4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid) linker, in which case the International Nonproprietary Name of the conjugate formed contains the word emtansine. DM1 and its attachment via these linkers result from ImmunoGen Inc research. Trastuzumab emtansine (T-DM1) is an anti-HER2/neu antibody-drug conjugate.

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