3-(Ethoxydimethylsilyl)propan-1-amine

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For R&D use only.

Catalog NO.：A812747
CAS No. : 18306-79-1
Molecular Formula：C₇H₁₉NOsi
Molecular Weight： 161.32

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	18306-79-1	Appearance	Colorless liquid
Catalog Number	A812747	MDL Number	MFCD00053947
Molecular Formula	C₇H₁₉NOsi	Molecular Weight	161.32
Boiling Point	166.5±23.0°C at 760 mmHg	Melting Point
Flash Point	136 °F	Density	0.857 g/mL at 25 °C(lit.)
Synonyms	3-[ethoxy(dimethyl)silyl]propan-1-amine
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	1993
Hazard Statements	H226-H315-H319-H335	Class	3
Precautionary Statements	P261-P305+P351+P338	Packing Group	Ⅲ

Description

LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2. LDN-212854 exhibits some selectivity for ALK2 in preference to other BMP type I receptors, ALK1 and ALK3, which may permit the interrogation of ALK2-mediated signaling, transcriptional activity, and function. LDN-212854 potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. The bone morphogenetic protein (BMP) signaling pathway has essential functions in development, homeostasis, and the normal and pathophysiologic remodeling of tissues. Small molecule inhibitors of the BMP receptor kinase family have been useful for probing physiologic functions of BMP signaling in vitro and in vivo and may have roles in the treatment of BMP-mediated diseases.

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H200	Explosives (Unstable Explosive)
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