BMH-21
- Catalog NO.:A861102
- CAS No. : 896705-16-1
- Molecular Formula:C21H20N4O2
- Molecular Weight: 360.41
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Product Details
CAS Number | 896705-16-1 | Appearance | |
Catalog Number | A861102 | MDL Number | MFCD27225377 |
Molecular Formula | C21H20N4O2 | Molecular Weight | 360.41 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-(2-(dimethylamino)ethyl)-12-oxo-11a,12-dihydro-5aH-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. BMH-21 does not cause phosphorylation of H2AX, a key biomarker activated in DNA damage stress. BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress. The findings also show that interference with DNA and DNA metabolic processes can be exploited therapeutically without causing DNA damage. |