4-Cyano-4'-n-octyloxybiphenyl

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For R&D use only.

Catalog NO.：A829047
CAS No. : 52364-73-5
Molecular Formula：C₂₁H₂₅NO
Molecular Weight： 307.43

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	52364-73-5	Appearance	white powder
Catalog Number	A829047	MDL Number	MFCD00075145
Molecular Formula	C₂₁H₂₅NO	Molecular Weight	307.43
Boiling Point	455.2°C at 760 mmHg	Melting Point	51-77 °C(lit.)
Flash Point	>230 °F	Density
Synonyms	4-Cyano-4'-n-octyloxybiphenyl;4'-Octyloxy-[1,1'-biphenyl]-4-carbonitrile
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H312-H315-H319-H332-H335	Class
Precautionary Statements	P261-P280-P305+P351+P338	Packing Group

Description

Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Check for active clinical trials or closed clinical trials using this agent.

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P301	IF SWALLOWED:
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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
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P370 + P378	In case of fire: Use … for extinction.
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P401	Store …
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P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Store at temperatures not exceeding … oC/…oF. Keep cool.

P501	Dispose of contents/container to..…
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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
H204	Explosives (Div 1.4)
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H280	Gases under pressure Compressed gas Liquefied gas Dissolved gas
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H300	Acute toxicity,oral (Category 1, 2)
H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
H303	Acute toxicity,oral (Category 5)
H304	Aspiration hazard (Category 1)
H305	Aspiration hazard (Category 2)
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H311	Acute toxicity,dermal (Category 3)
H312	Acute toxicity,dermal (Category 4)
H313	Acute toxicity,dermal (Category 5)
H314	Skin corrosion/irritation (Category 1A, B, C)
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H316	Skin corrosion/irritation (Category 3)
H317	Sensitisation, Skin (Category 1)
H318	Serious eye damage/eye irritation (Category 1)
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H320	Serious eye damage/eye irritation (Category 2B)
H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
H336	Specific target organ toxicity,single exposure; Narcoticeffects (Category 3)
H340	Germ cell mutagenicity (Category 1A, 1B)
H341	Germ cell mutagenicity (Category 2)
H350	Carcinogenicity (Category 1A, 1B)
H351	Carcinogenicity (Category 2)
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H361	Reproductive toxicity (Category 2)
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H371	Specific target organ toxicity, single exposure (Category 2)
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H373	Specific target organ toxicity, repeated exposure (Category 2)

H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
H402	Hazardous to the aquatic environment, acute hazard (Category 3)
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