1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione

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For R&D use only.

Catalog NO.：A877518
CAS No. : 2565-47-1
Molecular Formula：C₅H₆N₂O₃
Molecular Weight： 142.11

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Product Details

CAS Number	2565-47-1	Appearance
Catalog Number	A877518	MDL Number	MFCD00127915
Molecular Formula	C₅H₆N₂O₃	Molecular Weight	142.11
Boiling Point	279.7°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	2,4,6(1H,3H,5H)-Pyrimidinetrione,1-methyl-
Storage Condition	Store in a tightly closed container,in a cool and dry place

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Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.

1231929-97-7 (free base)

1231930-82-7 (mesylate)

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H200	Explosives (Unstable Explosive)
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H400	Hazardous to the aquatic environment, acute hazard (Category 1)
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