Ethyl 3-(4-bromophenyl)oxetane-3-carboxylate

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For R&D use only.

Catalog NO.：A902257
CAS No. : 1370035-61-2
Molecular Formula：C₁₂H₁₃BrO₃
Molecular Weight： 285.13

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Product Details

CAS Number	1370035-61-2	Appearance
Catalog Number	A902257	MDL Number	MFCD26402649
Molecular Formula	C₁₂H₁₃BrO₃	Molecular Weight	285.13
Boiling Point		Melting Point
Flash Point		Density
Synonyms	Ethyl 3-(4-bromophenyl)oxetane-3-carboxylate
Storage Condition	Store in a tightly closed container,in a cool and dry place

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Description

Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.

698387-09-6 (free base)

915942-22-2 (maleate)

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