1,2-Bis(chlorodimethylsilyl)ethane

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For R&D use only.

Catalog NO.：A806913
CAS No. : 13528-93-3
Molecular Formula：C₄₁H₅₆N₈O₁₄
Molecular Weight： 884.93

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NMR

Product Details

CAS Number	13528-93-3	Appearance
Catalog Number	A806913	MDL Number	MFCD00000505
Molecular Formula	C₄₁H₅₆N₈O₁₄	Molecular Weight	884.93
Boiling Point	198°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	4-(2-acetamidopropanoylamino)-5-[[1-[[2-[[2-[[1-[[2-amino-1-(carboxymethyl)-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-5-oxo-pentanoic acid
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	3261
Hazard Statements	H314	Class	8
Precautionary Statements	P280-P305+P351+P338-P310	Packing Group	Ⅱ

Description

Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.

698387-09-6 (free base)

915942-22-2 (maleate)

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