4-Nitrostyrene
- Catalog NO.:A897591
- CAS No. : 100-13-0
- Molecular Formula:C8H7NO2
- Molecular Weight: 149.15
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Product Details
CAS Number | 100-13-0 | Appearance | |
Catalog Number | A897591 | MDL Number | MFCD00041254 |
Molecular Formula | C8H7NO2 | Molecular Weight | 149.15 |
Boiling Point | 215.2°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 4-Nitrostyrene | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells. |