For R&D use only.

4-Fluoro-2,3-dimethylphenol

  • Catalog NO.:A19923
  • CAS No. : 77249-34-4
  • Molecular Formula:C8H9FO
  • Molecular Weight: 140.16
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Product Details

CAS Number 77249-34-4 Appearance Light yellow solid
Catalog Number A19923 MDL Number MFCD00153130
Molecular Formula C8H9FO Molecular Weight 140.16
Boiling Point 226.2±35.0°C at 760 mmHg Melting Point
Flash Point 110°C Density 1.124
Synonyms 4-Fluoro-2,3-dimethylphenol
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H302-H315-H319 Class
Precautionary Statements P261-P305+P351+P338 Packing Group

Description

Geldanamycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and inhibits its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis. Hsp90-geldanamycin complex. PDB 1yet Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via HSP90. Despite its potent antitumor potential, geldanamycin presents several major drawbacks as a drug candidate (namely, hepatotoxicity) that have led to the development of geldanamycin analogues.

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4-Fluoro-2,3-dimethylphenol
4-Fluoro-2,3-dimethylphenol