For R&D use only.

Bis(2,4,6-trimethylphenyl)methanone

  • Catalog NO.:A830966
  • CAS No. : 5623-45-0
  • Molecular Formula:C19H22O
  • Molecular Weight: 266.38
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Product Details

CAS Number 5623-45-0 Appearance
Catalog Number A830966 MDL Number
Molecular Formula C19H22O Molecular Weight 266.38
Boiling Point 340.6oC at 760mmHg Melting Point
Flash Point 141.2oC Density 1.004g/cm3
Synonyms Bis(2,4,6-trimethylphenyl)methanone
Storage Condition Store in a tightly closed container,in a cool and dry place

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Description

BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87-2243 mproves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts. BAY-87-2243 markedly decreased nuclear HIF-1α expression and pimonidazole hypoxic fraction already after 3 days of drug treatment. BAY-87-2243 prior to RT significantly reduced TCD50 from 123 to 100 Gy (p=0.037). Additional BAY-87-2243 application during RT did not decrease TCD50.

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Bis(2,4,6-trimethylphenyl)methanone
Bis(2,4,6-trimethylphenyl)methanone