2-(4-Oxopentyl)isoindoline-1,3-dione

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For R&D use only.

Catalog NO.：A875751
CAS No. : 3197-25-9
Molecular Formula：C₁₃H₁₃NO₃
Molecular Weight： 231.25

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	3197-25-9	Appearance	Light yellow powder
Catalog Number	A875751	MDL Number	MFCD06797717
Molecular Formula	C₁₃H₁₃NO₃	Molecular Weight	231.25
Boiling Point		Melting Point
Flash Point		Density
Synonyms	1H-Isoindole-1,3(2H)-dione,2-(4-oxopentyl)-
Storage Condition	Store in a tightly closed container,in a cool and dry place

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Description

BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87-2243 mproves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts. BAY-87-2243 markedly decreased nuclear HIF-1α expression and pimonidazole hypoxic fraction already after 3 days of drug treatment. BAY-87-2243 prior to RT significantly reduced TCD50 from 123 to 100 Gy (p=0.037). Additional BAY-87-2243 application during RT did not decrease TCD50.

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