PQR530

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For R&D use only.

Catalog NO.：A903446
CAS No. : 1927857-61-1
Molecular Formula：C₁₈H₂₃F₂N₇O₂
Molecular Weight： 407.43

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Product Details

CAS Number	1927857-61-1	Appearance
Catalog Number	A903446	MDL Number
Molecular Formula	C₁₈H₂₃F₂N₇O₂	Molecular Weight	407.43
Boiling Point		Melting Point
Flash Point		Density
Synonyms	(S)-4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine
Storage Condition	Store in a tightly closed container,in a cool and dry place

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Hazard Statements		Class
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Description

PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 µM. PQR530 showed excellent selectivity over a wide panel of kinases, as well as excellent selectivity versus unrelated receptor enzymes and ion channels. Moreover, PQR530 displayed potency in a panel of 44 cancer cell lines (NTRC OncolinesTM) to prevent cancer cell growth (mean value for GI50 of 426 nM). Oral application of PQR530 to mice resulted in a dose-proportional PK and demonstrated good oral bioavailability and excellent brain penetration.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
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