Ethyl 3-amino-1H-pyrrole-2-carboxylate

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For R&D use only.

Catalog NO.：A15420
CAS No. : 252932-48-2
Molecular Formula：C₇H₁₀N₂O₂
Molecular Weight： 154.17

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Product Details

CAS Number	252932-48-2	Appearance
Catalog Number	A15420	MDL Number	MFCD06797655
Molecular Formula	C₇H₁₀N₂O₂	Molecular Weight	154.17
Boiling Point	310.9°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	3-Amino-1H-pyrrole-2-carboxylic acid ethyl ester
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H332-H335	Class
Precautionary Statements	P261-P280-P305+P351+P338	Packing Group

Description

GSK343 is a potent, selective inhibitor of EZH2 with cellular activity. GSK343 inhibits EZH2 with an IC50 of 4nM and is over 1000-fold selective for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC50 of <200nM as measured by immunofluorescence. GSK343 exhibited limited effects on the growth of EOC cells in conventional two-dimensional (2D) culture. In contrast, GSK343 significantly suppressed the growth of EOC cells cultured in 3D matrigel extracellular matrix (ECM), which more closely mimics the tumor microenvironment in vivo. Notably, GSK343 induces apoptosis of EOC cells in 3D but not 2D culture. In addition, GSK343 significantly inhibited the invasion of EOC cells.

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H200	Explosives (Unstable Explosive)
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