PF-04929113 (Mesylate)

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For R&D use only.

Catalog NO.：A857805
CAS No. : 908115-27-5
Molecular Formula：C₂₅H₃₀F₃N₅O₄
Molecular Weight： 521.53

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Product Details

CAS Number	908115-27-5	Appearance
Catalog Number	A857805	MDL Number	MFCD20526334
Molecular Formula	C₂₅H₃₀F₃N₅O₄	Molecular Weight	521.53
Boiling Point	646.5±55.0°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	Glycine trans-4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl]amino]cyclohexyl ester;PF-04929113
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

PF-04929113, also known as SNX-5422; is a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX-5542 is rapidly converted to SNX-2112, which accumulates in tumors relative to normal tissues. SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
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