4-Fluoro-2-(hydroxymethyl)phenol

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For R&D use only.

Catalog NO.：A816775
CAS No. : 2357-33-7
Molecular Formula：C₇H₇FO₂
Molecular Weight： 142.13

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	2357-33-7	Appearance	Off-white crystal
Catalog Number	A816775	MDL Number	MFCD03412237
Molecular Formula	C₇H₇FO₂	Molecular Weight	142.13
Boiling Point		Melting Point
Flash Point		Density
Synonyms	4-fluoro-2-(hydroxymethyl)phenol
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word		UN Number
Hazard Statements		Class
Precautionary Statements		Packing Group

Description

ODM-201, also known as Darolutamide, is a new-generation, potent and selective androgen receptor (AR) inhibitor which is potential useful for treatment of castration-resistant prostate cancer (CRPC). ODM-201 is a full and high-affinity AR antagonist that, similar to second-generation antiandrogens enzalutamide and ARN-509, inhibits testosterone-induced nuclear translocation of AR. Importantly, ODM-201 also blocks the activity of the tested mutant ARs arising in response to antiandrogen therapies, including the F876L mutation that confers resistance to enzalutamide and ARN-509. In addition, ODM-201 reduces the growth of AR-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model. ODM-201 overcomes resistance to AR-targeted therapies by antagonizing both overexpressed and mutated ARs. ODM-201 is currently in a phase 3 trial in CRPC.

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