Irbinitinib

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For R&D use only.

Catalog NO.：A857335
CAS No. : 937263-43-9
Molecular Formula：C₂₆H₂₄N₈O₂
Molecular Weight： 480.52

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	937263-43-9	Appearance	Off-white powder
Catalog Number	A857335	MDL Number	MFCD22380467
Molecular Formula	C₂₆H₂₄N₈O₂	Molecular Weight	480.52
Boiling Point		Melting Point
Flash Point		Density
Synonyms	N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine;
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

937263-43-9 (Arry-380)

937265-83-3 (ARRY-380 analog)

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H200	Explosives (Unstable Explosive)
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