Methyl 6-bromo-5-fluoropyridine-2-carboxylate

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For R&D use only.

Catalog NO.：A905189
CAS No. : 1210419-26-3
Molecular Formula：C₇H₅BrFNO₂
Molecular Weight： 234.0

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Product Details

CAS Number	1210419-26-3	Appearance
Catalog Number	A905189	MDL Number	MFCD14698111
Molecular Formula	C₇H₅BrFNO₂	Molecular Weight	234.0
Boiling Point		Melting Point
Flash Point		Density
Synonyms	methyl 6-bromo-5-fluoropicolinate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H320-H335	Class
Precautionary Statements	P264-P270-P301+P312-P330	Packing Group

Description

Palbociclib, also known as PD-0332991, is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression. Palbociclib, was approved on February 3, 2015 as a treatment (in combination with letrozole) for patients with estrogen receptor-positive advanced breast cancer.

571190-30-2 (free base)

827022-32-2 (HCl)

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