2-(Difluoromethoxy)pyridin-4-amine

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For R&D use only.

Catalog NO.：A891867
CAS No. : 1211587-46-0
Molecular Formula：C₆H₆F₂N₂O
Molecular Weight： 160.12

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	1211587-46-0	Appearance	Off-white powder
Catalog Number	A891867	MDL Number	MFCD18261290
Molecular Formula	C₆H₆F₂N₂O	Molecular Weight	160.12
Boiling Point	263.3±35.0°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	2-(Difluoromethoxy)pyridin-4-amine
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. DM1 can also be linked to an antibody using the SMCC (4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid) linker, in which case the International Nonproprietary Name of the conjugate formed contains the word emtansine. DM1 and its attachment via these linkers result from ImmunoGen Inc research. Trastuzumab emtansine (T-DM1) is an anti-HER2/neu antibody-drug conjugate.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
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